Correlation Of Morphological Parameters With
Likelihood Of Thrombus Formation In
Intracranial Aneurysms
Author(s)
K. Shimano & Y. Nakagawa
Abstract
Accurate rupture prediction of intracranial aneurysms is crucial because not all
aneurysms rupture. With past reports that aspect ratio (AR) and size ratio (SR)
have significant correlations with rupture probability, these two morphological
parameters are regarded as promising for rupture prediction: an aneurysm with a
higher AR or SR is more likely to rupture than one with a lower AR or SR.
However, 100% reliability of prediction is not guaranteed even with these
parameters. It is necessary to clarify reasons for the high correlations of AR and
SR with rupture status and what is responsible for unsuccessful predictions. In
this paper, the authors discuss haemodynamic significance of the two parameters
with a special focus on stagnant flow and resulting thrombus formation, which
are considered to play important roles in the process of aneurysmal rupture.
Results with computational fluid dynamics and a platelet aggregation model are
also shown in order to demonstrate that stagnant flow and thrombus formation
can be observed even in an aneurysm with low AR and SR.
Keywords: intracranial aneurysm, rupture prediction, thrombus formation,
platelet aggregation, computational fluid dynamics.
1 Introduction
Intracranial aneurysms can cause fatal subarachnoid haemorrhages when they
rupture. Unruptured aneurysms can be found by means of magnetic resonance
imaging (MRI) or computed tomography (CT) before the patients have any
symptoms, and there are neurosurgical treatments to prevent future rupture of
Keywords
intracranial aneurysm, rupture prediction, thrombus formation,
platelet aggregation, computational fluid dynamics
Related Book
Other papers in this volume
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