Modelling Of Embolus Transport
And Embolic Stroke
Author(s)
I. D. Šutalo, A. Bui, K. Liffman & R. Manasseh
Abstract
Cerebral microembolism may lead to the restriction of blood supply due to
damaged blood vessel tissue (focal ischemia) which is increasingly seen as the
cause of cognitive deterioration including Alzheimer’s disease and vascular
dementia. The flow through fractal models of the peripheral vasculature of the
Anterior Cerebral Arteries (ACA) and Middle Cerebral Arteries (MCA) was
modelled. The multi-scale model of the cerebral vasculature was coupled with
blood flow and embolus transport models. The model incorporated asymmetric
bifurcation trees, embolus-vascular interactions and autoregulation. Simulations
were carried out where the embolus deposition rate, embolus diameter and
embolus introduction rate were varied. Increasing the embolus diameter and
embolus introduction rate increased the number of blocked terminal arteries to a
quasi steady-state. For a low embolus deposition rate the MCA and ACA
territory had the same embolization dynamics, even though, the MCA was larger
than the ACA. It was also found for a higher embolus deposition rate the MCA,
due to its more expansive structure, was less prone to occlusion than the ACA.
The results also showed the effect of a single blockage is expected to be less
severe in asymmetric flow than symmetric flow. This model will assist in
developing a better understanding into embolic stroke and effect of
Keywords
embolic stroke, microembolism, cerebral arteries, cerebral hemodynamics, ischemia, numerical models
Related Book
Other papers in this volume
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