A Dynamic Model Of The Pregnant
Myometrial Fasciculus
Author(s)
R. Miftahof & N. Akhmadeev
Abstract
A mathematical model of the pregnant myometrial fasciculus is proposed. It is
based on real anatomical and physiological data of its structure and function. The
model reproduces electromechanical wave phenomena in the myometrium under
normal physiological conditions and after application of different classes of
pharmacologically active compounds.
Keywords: human myometrium, fasciculus, electromechanical waves.
1 Introduction
In recent years the biomedical research on reproduction has been focused mainly
on molecular, neuroendocrine and pharmacological aspects of uterine activity. A
relatively small amount of work has been dedicated to modeling of the uterus per
se. Various approaches have been developed for uterine mechanics modeling
during parturition. The majority of them rely on assumptions of geometrical and
physical linearity [1, 2]. Results of numerical simulations obtained for different
values of parameters and constants resembled patterns of spontaneous
contractility observed during normal labor and reproduced voltageclamp traces
recorded experimentally on pregnant rats and human non-pregnant myometrial
cells. Although the existing models of the myometrium and the gravid human
uterus are based on the accurate application of general principles of solid
mechanics and incorporate some morphological data on the structure and
function of the organ, these models remain of limited biomedical value. New
integrative, biologically plausible models are needed to answer urgent questions
related to clinical problems of labor and delivery.
Keywords
human myometrium, fasciculus, electromechanical waves
Related Book
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