Micronucleus Frequencies In Lymphocytes And
Buccal Cells In Formaldehyde Exposed Workers
Author(s)
S. Costa, F. Brandão, M. Coelho, C. Costa, P. Coelho,
S. Silva, B. Porto & J. P. Teixeira
Abstract
Formaldehyde (FA) is a high-volume production chemical produced worldwide
with a large range of industrial and medical uses. Listed, since 2004, by IARC as
a human carcinogen, FA status was recently revised by the US government who
reclassified this compound as known to be a human carcinogen. Both
reclassifications are based on sufficient evidence of carcinogenicity from
epidemiologic studies, supporting data on mechanisms of carcinogenesis and
experimental evidence in animals. The highest level of human exposure to FA
occurs in occupational settings. Consistent findings of increased risks of certain
types of rare cancers were found among workers with higher measures of
exposure to FA (exposure level or duration). The aim of the present study was to
assess the genotoxic effects of occupational exposure to FA. A group of
pathology and anatomy workers was evaluated for micronuclei in lymphocytes
and in exfoliated buccal cells. Genotoxic endpoints are of great interest in the
risk assessment of occupational carcinogens because they precede by a long time
the potential health effects, thus offering a greater potential for preventive
measures. Micronuclei in lymphocytes and in exfoliated buccal cells were
significantly higher in the exposed subjects when compared with controls. Air
sampling was performed in the workers’ breathing zone for representative
working periods and an 8h-time weighted average was assessed. Results
Keywords
formaldehyde, genotoxicity, micronucleus test, lymphocytes, exfoliated buccal cells
Related Book
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