Design And Evaluation Of A Breath Analysis System For Occupational
Exposure Assessment
Author(s)
X.L. Soldat and X.D. Thrall
Abstract
Design and evaluation of a breath analysis
system for occupational exposure assessment
K. L. Soldat and K. D. Thrall
Pacific Northwest National Laboratory, United States of America
Abstract
Exposure assessment is an integral part of industrial hygiene and occupational
health. To ensure the health and safety of workers, integrated industrial hygiene
methodologies often include biological monitoring strategies. Exhaled breath is
an ideal matrix for measuring volatile biomarkers, particularly since the non-
invasive collection of breath may improve volunteer participation. A real-time,
field-portable system was developed to analyze undiluted exhaled air from
experimental animals and humans. The system combines 1) an ion-trap mass
spectrometer capable of atmospheric sampling; 2) a breath interface for continual
analysis of the exhaled breath stream; 3) chemical dosimeters that are analyzed in
the field/workplace; and 4) physiologically based pharmacokinetic (PBPK)
models to es
Keywords
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