Thread As A Substrate For Low-cost
Point-of-care Diagnostics
Author(s)
X. Li, D. Ballerini, J. Tian & W. Shen
Abstract
This study presents new applications of thread-based microfluidic systems in
chemical and biochemical diagnostics. Our recent reports have demonstrated the
capability of fabricating low-cost microfluidic devices using ubiquitous
multifilament materials such as threads. The gaps between fibres in threads
provide capillary wicking channels for liquid transport; therefore, liquid can
penetrate along threads without the need of external forces. The new threadbased
system, combined with the cheap dosing tools, is capable of easily and
rapidly semi-quantifying the concentration of analytes in human body fluids. The
utility of this system is further extended for the rapid and easy blood grouping
with only small amount of whole blood (~ 2 μL for ABO blood typing), which is
an essential test before blood transfusion. These low-cost and portable
microfluidic devices are easy to fabricate, simple to use, and do not require
powers such as electricity; thus providing a desirable analytical platform for
point-of-care applications.
Keywords: low-cost diagnostics, microfluidic, point-of-care, thread-based.
1 Introduction
Modern microfluidic systems have been designed to carry out complicated
analytical measurements for a range of applications [1]. However, such
sophisticated microfluidic systems are usually expensive and the users always
need to be trained to acquire the operation skills, thus restricting the
practicability of these systems. The increasing needs of low-cost microfluidic
devices which are readily accessible to average users, especially those people
from under-developed areas or remote regions compel the development of new
Keywords
low-cost diagnostics, microfluidic, point-of-care, thread-based
Related Book
Other papers in this volume
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