Interaction Profiles For Simple Mixtures:
Mixtures With Radioactive Chemicals
Author(s)
H. R. Pohl, M. Fay & J. F. Risher
Abstract
The Agency for Toxic Substances and Disease Registry (ATSDR) program for
chemical mixtures risk assessment has prepared a guidance document (Guidance
Manual for the Assessment of Joint Toxic Action of Chemical Mixtures) that
instructs how to conduct health risk assessment for chemical mixtures. ATSDR
also develops documents called \“interaction profiles” to assess risks associated
with exposure to specific chemical mixtures. The assessment method has been
applied in practice during consultations in communities around hazardous waste
sites.
Interaction profiles are written for mixtures of concern that are on ATSDR’s
priority list of mixtures at hazardous waste sites, such as mixtures of VOCs most
often found in water and mixtures of metals most often found in contaminated
soils. Similarly, interaction profiles on persistent lipophilic chemicals found in
fish and breast milk provide information on risk associated with exposures in
everyday life. In support of the US Geological Survey (USGS), ATSDR has
developed an interaction profile for a mixture of pesticides found in well water.
In addition, interaction profiles have been developed for Department of Energy
(DOE) and National Aeronautics and Space Administration (NASA) sites.
These interaction profiles were unique in evaluating risk associated with
exposures to radioactive and non-radioactive chemicals. Weight-of-evidence
methodology was used to assess the joint toxic action for most of the mixtures.
For most mixtures profiled so far, a target-organ toxicity dose modification of
the hazard index approach was utilized for conducting exposure-based
assessments of noncancer health hazards.
Keywords: chemical mixtures, risk assessment, radioactive chemicals, additivity,
joint toxic action.
Keywords
chemical mixtures, risk assessment, radioactive chemicals, additivity,
joint toxic action.
Related Book
Other papers in this volume
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