Effect Of Remediation Measures On Exposure
And Liver Detoxification Capacity Of Children
Author(s)
O. Herbarth, M. Bauer, U. Franck, P. Krumbiegel,
M. Rehwagen, U. Rolle-Kampczyk & H. Weiß
Abstract
The efficiency of remediation measures in once heavily polluted industrial areas
is conventionally assessed by its decreasing pollution burden. To what extent the
redevelopment contributes to an improvement in health is important. To have a
valid physiological parameter or/and indicator of exposure as well as the
methodology to measure both bio- and/or effect-monitoring is decisive.
An epidemiologic cohort study was conducted, whereby kindergarten
children from a heavily polluted industrial area and a control one were observed
over a prolonged period of time under conditions of redevelopment. The regionspecific
external exposure was assessed by 27 volatile organic compounds. The
effect was assessed with a specially developed stable-isotope-based diagnostic
test ([15N]methacetin test) measuring the liver’s detoxification capacity.
The children’s internal load reflected the significant differences in exposure
to chlorinated compounds. The ratio of concentrations for the indicator
components (chlorinated compounds) was 2.3 for exposed and control children.
The pollution-exposed children showed a 6% lower liver detoxification capacity.
A reduction in pollution by about 70% was reflected in an improved liver
detoxification capacity. The difference between polluted and control area was no
longer significant.
Prolonged exposure effects to low concentrations of xenobiotics can disturb
hepatic functioning. This stable-isotope-based test can be used as a tool to
determine health effects of multi-component exposure when the predominant
pollutant is taken into account. The presented method appears well suited for
bio-effect-monitoring for the purpose of screening and testing the efficaciousness
of the remediation activities.
Keywords: children, intervention study, exposure associated liver detoxification
capacity, chlorinated hydrocarbons.
Keywords
children, intervention study, exposure associated liver detoxification
capacity, chlorinated hydrocarbons.
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