The Concept Of A Functional Unit Of The Gut
Author(s)
R.N. Miftahof & E.M. Fedotov
Abstract
The concept of a functional unit (FU) as the basic element of the gut as a mechanical
structure is presented. The FU is a geometrically and morphofunctionally
defined part of the gut modeled as a soft cylindrical orthotropic shell. The wall
of the shell formed of the two distinct layers of muscle – the longitudinal and
circular, respectively. The myoelectrical activity of both layers is controlled by
pacemaker cells, analogous to interstitial cells of Cajal type MP (ICC-MP). The
mechanical properties of the wall of the FU are nonlinear and deformations are
finite. The dynamics of the generation of coupled electromechanical waves of
contraction/relaxation as a response to a discharge of ICC-MP and an increased
in intraluminal pressure is studied numerically.
1 Intr
Keywords
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