The Liquid-liquid Interface
Under Planetary Rotation
Author(s)
C. S. König & I. A. Sutherland
Abstract
Countercurrent chromatography is a liquid-liquid partition chromatography
method allowing high-resolution purifications. It utilises the hydrodynamic
behaviour of two immiscible liquid phases in coil columns undergoing a
planetary motion generated by a synchronous coil planet centrifuge.
In this study planetary rotation is applied to liquid-liquid flows in two types
of ring geometries. The influence of the epicyclic force field is studied by
applying a variety of different operating conditions, namely rotational speed and
the ratio of the planet and sun radii known as the beta value. The results show
that variation of the beta value has far greater influence on phase distribution
than variation of the rotational speed.
1 Introduction
Countercurrent chromatography (CCC) separates compounds from mixtures on
the basis of their partition or distribution between two immiscible solvents. The
process utilises the hydrodynamic behaviour of the two liquid phases in coil
columns undergoing a planetary motion generated by a synchronous coil planet
centrifuge. The centrifugal force field applied to the coiled columns promotes the
retention of stationary phase against a continuous flow of mobile phase, while
providing efficient mixing between the two solvent phases to enable the partition
process. A series of simultaneous mixing and settling zones occur along the
length of the tubing. This mixing and settling process and the mass transfer
between the phases are the key elements for successful high-resolution liquidliquid
chromatography [1,2]. Although phase distribution and phase-mixing
phenomena, which are fundamental to CCC, are directly linked to the gravity
field, its influence is still not fully understood [2-4].
Keywords
Related Book
Other papers in this volume
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