Integration Of Computer Model Of Drug Delivery With Human Subject
Testing
Author(s)
T. Martonen, D. Hwang & J. Fleming
Abstract
Integration of computer model of drug
delivery with human subject testing
T. art on en', D. wan^^ & J. ~ l e r n i n ~ ~
I National Health and Environmental Effects Research Laboratory,
Research Triangle Park, and Department of Medicine, University of
North Carolina, USA
2 IBM, Research Triangle Park, USA
3~outhampton General Hospital, UK
Abstract
Mathematical models may be used a priori to determine experimental
conditions to facilitate the administration of inhaled pharmacologic drugs. By
regulating inhaled particle sizes and patient ventilatory parameters, aerosolized
medicines can be targeted to appropriate sites to elicit optimum therapeutic
effects. In our clinical laboratory we have employed computer simulations as a
methodology to treat respiratory diseases per se, and are presently advocating
inhalation as a novel technique for systemic delivery of pharmaceuticals to other
organs. In both types of models, it is imperative that the morphology of the
human respiratory system be anatomi
Keywords
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