A Mathematical Model Approach To A
Glycerolysis Reaction For
Monoacylglycerol Production
Author(s)
B. Cheirsilp & A. H-Kittikul
Abstract
Monoacylglycerol emulsifiers commonly employed in the food, cosmetic and
pharmaceutical industries can be produced by a glycerolysis reaction using
lipase. The concentrations of two substrates (palm olein and glycerol) in the
glycerolysis reaction were strictly interdependent. Therefore, it was impossible
to perform a classic kinetic study by fixing the concentration of one substrate and
changing the concentration of the other substrate. Here, a mathematical model
approach is a useful tool to independently assess the effects of hypothetical
changes in the concentrations of each. In essence, this analysis permits one to
examine various aspects associated with the dynamics and equilibrium of the
glycerolysis reaction that cannot be investigated experimentally. In this study a
mathematical model, taking into account the mechanism of the glycerolysis
reaction for monoacylglycerol production using immobilized lipase, has been
developed. From the proposed model, the effects of varying the initial
concentrations of substrates on the initial production rate and yield of
monoacylglycerol were simulated. The most significant finding from simulation
was that an increase in the initial concentration of triacylglycerol leads to an
increase in the initial production rate of monoacylglycerol, but there is a limit
beyond which increasing the initial concentration of triacylglycerol results in a
low yield of monoacylglycerol. The simulation results show that mostly glycerol
reacts with fatty acid of triacylglycerol to produce monoacylglycerol in a
glycerolysis reaction. From a thermodynamic standpoint, a greater incorporation
of glycerol is expected because a higher concentration of this acyl acceptor
should shift the equilibrium towards a greater glycerolysis reaction.
Keywords: glycerolysis, lipase, mathematical model, monoacylglycerol.
Keywords
glycerolysis, lipase, mathematical model, monoacylglycerol.
Related Book
Other papers in this volume
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