Composite Model Of A Hematopoietic System
With Clone Competition
Author(s)
M. Rusinov, S. Kulikov & L. Uvarova
Abstract
This paper is dedicated to the development of a human hematopoietic system
model, its identification and investigation of the roles of polyclonal and complex
feedback in defining the behaviour of the system. The main purpose of the model
framing is the study of the interaction and the possible pathogenetic role of
simultaneously coexisting distinct lines of blood, which develop in parallel. The
article proposes a classification system for human hematogenesis models based
on following a key principle: the method of describing the age structure of cell
population. Based on the analysis of said classification certain system features,
which have not been considered previously, stand out. To take them into
account, we propose a model based on the McKendrick–von Foerster equation.
This paper describes the features and limitations of this model and discusses
further development of the model
Keywords: mathematical model, hematopoietic system, stem cell, hematopoiesis.
Keywords
Keywords: mathematical model, hematopoietic system, stem cell, hematopoiesis.
Related Book
Other papers in this volume
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