Influence Of Hydrolysis On The Mechanical
Properties Of PLA Nanofibers
Author(s)
K. Tanaka, M. Ono & T. Katayama
Abstract
Due to the high surface area to volume ratio, polymer nanofibers are expected to
be used for a wide range of applications such as tissue engineering, drug
delivery, wound dressing scaffolds, artificial blood vessels and so on.
Poly L-lactic acid (PLLA) is a thermoplastic resin with a melting temperature
of about 180°C. Its melting temperature is not high enough in some applications.
An equimolar mixture of poly L-lactic acid (PLLA) and poly D-lactic acid
(PDLA) can be crystallized into a stereocomplex-type PLA (SCPLA). The
melting point of a stereocomplex crystal is 50°C higher than that of PLLA. It has
been reported that SCPLA is more stable against hydrolysis than PLLA.
Poly lactic acid (PLA) is one of a few polymers that are practically applied as
various medical materials such as implants and sutures. Since PLA is easily
hydrolyzed in a water environment, the effect of water absorption on the
mechanical properties should be investigated.
In this study, the influence of hydrolysis on the mechanical properties of
PLLA and SCPLA nanofiber were investigated by a single nanofiber tensile test.
The tensile strengths of PLLA and SCPLA nanofiber were 141MPa and
165MPa, respectively. The immersing in water at 37°C for 4 weeks does not
affect the mechanical properties of either PLLA or SCPLA.
Keywords: electrospinning, nanofiber, poly L-lactic acid (PLA), tensile test,
stereocomplex-type PLA, hydrolysis.
Keywords
Keywords: electrospinning, nanofiber, poly L-lactic acid (PLA), tensile test,
stereocomplex-type PLA, hydrolysis.
Related Book
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