Influence Of Fine Particulate Matter (PM2.5) On
The Function Of Human Immune Cells
Author(s)
T. Brzicová, I. Lochman, P. Danihelka, A. Lochmanová,
K. Lach & V. Mička
Abstract
Fine airborne particulate matter (PM2.5) evidently contributes to morbidity and
mortality of exposed populations, particularly in densely populated industrial
areas with heavy traffic. Research on the toxic effects of PM2.5 has indicated that
numerous adverse health consequences of exposure to PM2.5 result from their
immunomodulatory and immunotoxic effects. Therefore, immunological assays
are supposed to be a suitable screening tool for evaluating the harmful potential
of PM. Using selected in vitro immunological assay, we have evaluated changes
in both humoral a cell-mediated components of the innate and acquired immune
response. Generation of reactive oxygen species was assessed using a
chemiluminescence assay. Stimulation effects of the PM sample on the key
component of cell specific immunity was monitored using a lymphocyte
proliferation assay. Allergenic potential of the PM sample was investigated by a
basophil degranulation assay. Changes in levels of selected cytokine were
monitored using a multiplex technology ALBIA. Even if certain
immunomodulatory effects of short-term incubation of the PM2.5 sample in
whole blood cultures were observed using in vitro immunological assays,
changes in evaluated immune response parameters were not significant to prove
impact on the immune cells’ functions of healthy persons. However, health risks
of long-term exposure, especially for individuals with genetic predisposition to
certain diseases or already existing diseases, cannot be excluded.
Keywords: PM2.5, immunological assays, oxidative stress, inflammation,
allergy, lymphocyte proliferation, cytokines.
Keywords
PM2.5, immunological assays, oxidative stress, inflammation,
allergy, lymphocyte proliferation, cytokines
Related Book
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