Evaluating Safety Of Drinking Water Using
Animal Cell Bioassays
Author(s)
G. K. Luk
Abstract
Disinfection byproducts (DBPs) such as trihalomethanes (THMs), haloacetic
acids (HAAs), 3-chloro-4-(dichloromethyl)-5-hydroxyl-2(5H)-furanone (MX)
and other hazardous compounds are produced by chlorination of raw water in the
water treatment plants. Most chlorinated by-products are formed by the
interaction of chlorine and natural organic matter (NOM) such as fulvic and
humic acids, which are present in most surface waters. Many of these byproducts
are suspected to be mutagenic or carcinogenic in nature. The objective
of the paper is to demonstrate the effectiveness of bioassay-directed research in
evaluating the safety of chlorinated drinking water, and to investigate the effect
of pH on the genotoxicity of chlorinated sample water.
Keywords: disinfection byproducts, chlorination, drinking water, bioassays.
1 Introduction
Although water disinfection has been quite successful in eliminating many acute
waterborne diseases in the developed world, many potential health hazards
related to disinfection by-products (DBPs) have been reported [1, 2].
Epidemiological studies demonstrate that many potential health risks such as
cancers of the stomach, pancreas, kidney, bladder, and rectum, as well as
Hodgkin’s and non-Hodgkin’s lymphoma have been linked to exposure to
DBPs [3]. DBPs such as trihalomethanes (THMs), haloacetic acids (HAAs), 3-
chloro-4-(dichloromethyl)-5-hydroxyl-2(5H)-furanone (MX) and other
hazardous compounds are produced by chlorination and other disinfection
methods of raw water in the water treatment plants. Most chlorinated byproducts
are formed by the interaction of chlorine and natural organic matter
Keywords
disinfection byproducts, chlorination, drinking water, bioassays.
Related Book
Other papers in this volume
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