Design Of Scaffolds With Computer Assistance
Author(s)
H. A. Almeida, P. J. Bártolo & J. C. Ferreira
Abstract
Advanced rapid prototyping techniques are being used to fabricate scaffolds for
tissue engineering with controlled architecture. These techniques combine
computer-aided design with bio-manufacturing tools to produce 3D structures in
a multitude of materials. These scaffolds must be biocompatible, biodegradable,
with appropriate porosity, pore structure and distribution, having both surface
and structural compatibility. Structural compatibility of the host tissue
corresponds to an optimal adaptation to the scaffold mechanical behaviour,
referring to its mechanical properties and deformation capability. This paper
proposes a computer tool to predict the mechanical behaviour of scaffolds with
different topological architectures and levels of porosity. The influence of the
interaction between biofluids and the scaffold is also presented.
Keywords: scaffolds, mechanical behaviour, tissue engineering and biofluid
mechanics.
1 Introduction
The loss or failure of an organ or tissue is a frequent, devastating and costly
problem in health care. Currently, this loss or organ failure is treated by either
transplanting organs from one individual to another or performing surgical
reconstructions by transferring the tissue from one location in the human body to
the diseased site. The need for substitutes to replace or repair tissues or organs
due to disease, trauma, or congenital problems is overwhelming. In 2003, in the
USA alone, 87717 patients were waiting for organ transplantation [1]. This
Keywords
scaffolds, mechanical behaviour, tissue engineering and biofluid
mechanics.
Related Book
Other papers in this volume
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