A Mathematical Model For The Diagnosis And
Treatment Of Idiopathic Intracranial
Hypertension
Author(s)
W. D. Lakin, S. A. Stevens, N. J. Thakore &P. L. Penar
Abstract
Idiopathic intracranial hypertension (IIH) is a syndrome of unknown cause characterized
by elevated intracranial pressure (ICP). A stenosis of the venous sinus
is observed in many patients suffering from IIH. The role that this feature plays
in the etiology of IIH has been a matter of dispute. A lumped-parameter model
of intracranial pressure dynamics that accommodates venous sinus stenosis via a
Starling-like resistor has been developed to study the etiology, diagnosis, and treatment
of IIH. In the absence of the Starling-like resistor, the system has a unique
asymptotically-stable steady-state with normal pressures.With this type of resistor
present, a second, asymptotically-stable steady-state may exist. This state is characterized
by elevated ICP concurrentwith a compressed venous sinus. It is hypothesized
that IIH is a physiological manifestation of this elevated steady-state, that
the primary cause of IIH is a compressible, as opposed to rigid, venous sinus, and
that the observed stenosis is a necessary characteristic of the elevated steady-state.
Simulations suggest a possible diagnostic technique for IIH, and the efficacy of
various treatment options is examined. Results also indicate that the venous sinus
stenosis may persist even after treatment has reduced the elevated ICP of IIH.
1 Introduction
Idiopathic intracranial hypertension (IIH), also called pseudotumor cerebri and
benign intracranial hypertension, is a syndrome of unknown cause characterized
by elevated intracranial pressure (ICP) without evidence of ventricular dilatation,
mass lesion, or dural sinus thrombosis. It presents with symptoms of headache,
Keywords
Related Book
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