Modeling Pathological Intracranial Pressure
Waveforms In Idiopathic Intracranial
Hypertension
Author(s)
S. A. Stevens, W. D. Lakin, N. J. Thakore, P. L. Penar
& J. Stimpson
Abstract
Idiopathic intracranial hypertension (IIH) is a syndrome of unknown cause characterized
by elevated intracranial pressure (ICP). By representing an abnormally
collapsible sinus with a downstream Starling-like resistor, our previous modeling
efforts have produced explanations for various phenomenon associated with IIH.
Recent reports indicate that many patients with chronic daily headaches have been
found to actually be suffering from IIH without papilledema (IIWOP). Moreover,
these patients often demonstrate hypertensive B-waves and plateau-like waves
upon continuous ICP monitoring. Our previous results did not produce such pathological
wave-forms. The current model, described here, resolves this deficit by representing
a semi-collapsible sinus by a refined resistor based on experimental data.
With this revision the model exhibits low frequency, high amplitude ICP waves
in milder cases of sinus collapsibility. As collapsibility increases further, so does
the duration of the waves until they are replaced by two stable states, one of normal
pressures and one of elevated pressures. In this domain the model behaves
in much the same way as our previous work. Thus, the current model reproduces
the results of previous versions and additionally exhibits the high amplitude spikes
and wave-forms seen clinically in milder cases of IIH.
Keywords
Related Book
Other papers in this volume
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