Diurnal Variation Of Salivary Cortisol And
Amylase Activity In Fatigued State
Author(s)
Y. Nakajima, T. Takahashi & M. Yamaguchi
Abstract
Saliva has great potential as a bio-fluid for point-of-use measurement of the
human stress response. The purpose of this study was to evaluate the diurnal
variation of salivary cortisol (CORT) and salivary amylase activity (SAA) under
the condition of a fatigued state. The subjects were 11 emergency medical
doctors who worked for the Department of Emergency and Critical Care
Medicine in 24 h-shifts, and their diurnal variations were measured three times in
one month during the 24h-shift workday. As a control experiment, 6 subjects’
diurnal variations were measured during a holiday period. The saliva samples
were collected 4 times in total during an examination. The mean CORT of a
workday showed its lowest value of 1.07 ± 0.55 ng/ml before sleep (24:00), and
was highest at 4.76 ± 3.16 ng/ml at the start of a daytime duty (9:00) (p < 0.01).
In contrast, the mean CORT of a holiday showed its lowest value of 1.48 ± 1.00
ng/ml in the afternoon and a highest value of 4.74 ± 2.76 ng/ml the next morning
(p < 0.05). The mean SAA of a workday showed its lowest value of 59.3 ± 31.5
kU/l during a daytime duty (12:00 – 14:00) and was highest at 112.7 ± 90.1 kU/l
at the start of night-time duty (18:00). These salivary biomarkers CORT and
SAA on both workdays and holidays showed diurnal variation. In particular, the
diurnal variation of CORT followed a well-defined ‘bath-tub’ shaped curve. A
negative correlation of –0.36 was observed between the individual’s CORT and
SAA in workdays and of –0.62 in holidays, as determined by using the dynamic
programming method. It was suggested that the fatigued state of humans is
possibly reflected in the diurnal variations of CORT and SAA.
Keywords: diurnal variation, cortisol, amylase, fatigued state, dynamic
programming method.
Keywords
diurnal variation, cortisol, amylase, fatigued state, dynamic
programming method
Related Book
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