The Cardiac Cell Model At Normal And High Pacing Rates
With Markovian Representations Of Gating Processes
(Computer Simulation Study)
Author(s)
B. Kogan, J. Better & I. Zlochistyy
Abstract
The cardiac cell model at normal and high
pacing rates with Markovian representations of
gating processes
(Computer simulation study)
B. Kogan, J. Better & I. Zlochistyy
Computer Science Department, University of California, Los Angeles,
California, USA
Abstract
Over the past years significant results have been achieved in the mathematical
modeling and computer simulation of action potential generation and propagation
using Hodgkin-Huxley formalism. The development of the single channel
clamp experiment technique has provided new experimental data, and also led to
a Markovian formulation of the ion channels gating processes. The advantages of
this formulation are: it makes the artificial Hodgkin-Huxley assumption of mutual
independence of gating processes unnecessary and also opens the possibility
of simulating the effects of drugs, toxins and genetic defects in channel proteins
on the behavior of cardiac cells.
The comparison of the effect of Markovian and Hodgkin-Huxley representations
for
Keywords
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