Metabolic System Dynamics: Lumped And Distributed Models
Author(s)
G. M. Saidel, J.A. DiBella II & M. E. Cabrera
Abstract
Metabolic system dynamics: lumped and
distributed models
G.M. aid el''^, J.A. DiBella 11' & M.E. ~ a b r e r a " ~ ' ~
I Department of Biomedical Engineering, Case Western Reserve University
Cleveland, OH, USA
2 Center for Modeling Integrated Metabolic Systems
Case Western Reserve University
3 Department of Pediatrics, Rainbow Babies and Children's Hospital
University Hospitals of Cleveland
Abstract
A quantitative understanding of the complexity of cellular metabolism integrated
within a tissue-organ system requires mathematical modeling and simulation.
Physiologically based dynamic models that incorporate cellular metabolic
reactions and transport processes of many chemical species may be spatially
lumped andlor distributed. Such models allow quantitative evaluation of
metabolic pathways and regulatory mechanisms under normal and abnormal
conditions. In our Center for Modeling Integrated Metabolic Systems (MIMS), we
are developing a general integrative whole-body model that relates cellular
Keywords
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