A Modelling Study Of The Cardiovascular Response To Exercise
In Patients With Mitral Stenosis
Author(s)
E. Magosso & M. Ursino
Abstract
A modelling study of the cardiovascular
response to exercise in patients with mitral
stenosis
E. Magosso & M. Ursino
Department of Electronics, Computer Science, and Systems,
University Of Bologna, Italy
Abstract
The objective of the present study was to quantitatively investigate the effect of
mitral valve stenosis on the hemodynamics, both at rest and during exercise. The
analysis was performed by means of a mathematical model. The model includes
the pulsating heart, the pulmonary and systemic circulation, and the main
mechanisms involved in exercise response: the ventilatory adjustments to
exercise, the muscle and respiratory pump, the local metabolic vasodilation in
active muscles, the central motor command, the arterial baroreflex, and the lung
inflation reflex. With basal parameter values, the model is able to reproduce the
cardiovascular response measured in healthy human subjects to different levels
of aerobic exercise. Simulation of moderate mitral stenosis conditions shows that
the
Keywords
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