Bone Remodelling Considering Drug Effects On A Damage Mechanics Model
Author(s)
M. E. Zeman, J. M. Garcia, M. Cerrolaza & M. Doblaré
Abstract
Bone remodelling considering drug effects on a
damage mechanics model
M. E. ema an', J. M. ~ a r c i a ~ , M. ~errolaza' & M. ~ o b l a r e ~
1 Bioengineering Centre, Faculty of Engineering, Central Universi~ of Venezuela
2,Structural Mechanics Division, Mechanical Eng. Dep. Centro Politecnico
Superior, Universiiy of Zaragoza, Spain
Abstract
It is well known that mechanical loads are one of the main factors that affect bone
remodelling process. This phenomenon is widely applied to the study of
prosthetic replacement, for example hip prosthesis. Elderly people are the most
common patient to receive a hlp replacement surgery.
Alendronate is a drug that is being used to increase bone mineral content in
patients with poor bone quality.
This work uses a mechanical model based on damage mechanics, which
considers bone's porosity as the damage variable, a mechanical stimulus
associated thermodynamically to this variable, a damage criterion and an
evolution damage law. Our approach simulates the degre
Keywords
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