Algorithm For Synchronization Of Electroporation
Pulse Delivery With Electrocardiogram
Author(s)
B. Music, T. Jarm, F. Jager & D. Miklavčič
Abstract
Algorithm for synchronization of
electroporation pulse delivery with
electrocardiogram
B. Music1, T. ~arrn', F. ~ a ~ e r ~ & D. Miklav~i~'
I University of Ljubljana, Faculty of Electrical Engineering, Slovenia.
2 University of Ljubljana, Faculty of Computer and Information Science,
Slovenia.
Abstract
Electrochemotherapy is a local treatment of tumors in which high voltage
electric pulses are used for permeabilization of cell membrane (electroporation)
thus enabling increased entry of chemotherapeutic molecules into tumor cells.
Application of electroporation pulses to tumors located close to the heart muscle
could lead to fibrillation of the heart if the pulses are delivered during the
vulnerable period of the heart or if the pulses coincide with heart arrhythmias
due to lowered threshold for fibrillation. We present an algorithm based on the
analysis of a single-lead electrocardiogram. The algorithm enables safe use of
electrochemotherapy by allowing the electroporation pulses to be delivere
Keywords
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