Increased Pulse Repetition Frequency For Effective And
Less Painful Electrochemotherapy
Author(s)
D. Miklavčič, G. Pucihar, L. M. Mir, M. Puc, K. Flisar,
A. Maček Lebar, M. Mali, G. Serša, S. Kranjc,
M. Čemažar, M. Petkovšek & J. Nastran
Abstract
Increased pulse repetition frequency for
effective and less painful electrochemotherapy
D. ~iklavCiC', G. Pucihar', L. M. Mir2, M. Pucl, K. Flisarl,
A. MaCek ~ebar', M. Mali1, G. Ser5a3, S. Kranjc3, M. Cemaiar",
M. ~etkov~ek' & J. Nastran'
l~aculty of Electrical Engineering, University of Ljubljana, Slovenia
~ U M R 8532 CNRS: Institute Gustave-Roussy, France
3~e~artment of tumor biology, Institut of Oncology, Slovenia
Abstract
Electrochemotherapy is a technique where electric pulses in combination with
chemotherapeutic agents are applied to tumor cells. In general, patients fmd
electrochemotherapy tolerable, in spite of unpleasant sensations associated with
contraction of muscles located in the vicinity of the electrodes. Usually a train of
eight electric pulses with repetition frequency of 1 Hz is applied to the tumors and
each pulse in the train provokes muscle contraction. The use of pulses with
repetition frequency higher than the frequency of tetanic contraction would
represent reduced n
Keywords
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