Alkylphenols And Bisphenol-A And Its
Chlorinated Derivatives In Adipose
Tissue Of Children
Author(s)
N. Olea, J. P. Arrebola, J. Taoufiki, R. Fernández-Valades,
R. Prada, N. Navea, J. M. Molina-Molina & M. F. Fernandez
Abstract
Bisphenol-A (BPA) is a plastic monomer and plasticizer used in the production
of polycarbonate and epoxy resins. Alkylphenols are used as antioxidants and in
the synthesis of industrial detergents, in toiletries, and as spermicides. Because
of their endocrine disrupting properties, there is strong interest in studying their
contribution to human exposure, especially in children. Octyl (OP) and
nonylphenol (NP), bisphenol-A (BPA) and its chlorinated derivatives
(Cl(x)BPA) were investigated in adipose tissue of 86 children in Spain. OP and
NP were above the limit of detection (LOD) in 21 and 31 out of 86 samples,
respectively. Means (SD) of OP and NP were 6.27 (6.63) and 38.27 (56.91) ng/g
of adipose tissue, respectively. BPA was above LOD in 53 out of 86 samples
(62%). Among Cl(x)BPA, Cl2-BPA was the most frequent (99%) and abundant,
followed by Cl-BPA (64%) and Cl4-BPA (12%). Means (SD) of BPA, Cl-BPA,
Cl2-BPA, Cl3-BPA and Cl4-BPA were 17.46 (14.82), 7.32 (4.26), 14.45 (9.79),
4.14 (1.35) and 3.54 (1.94) ng/g, respectively. There are no published data on
alkylphenols and BPA in human adipose tissue or on Cl(x)BPA in adipose tissue
or blood, limiting comparisons. However, these levels are higher than BPA
concentrations reported to stimulate molecular endpoints in vitro and are at
levels observed to induce effects in animal models. Further research is needed to
explore their combined effects on children health, and to follow trends in human
exposure if uses of these chemicals are to be regulated.
Keywords: bisphenols, alkyphenols, children exposure.
Keywords
bisphenols, alkyphenols, children exposure.
Related Book
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