The Recalcitrance Of Clofibric Acid To
Microbial Degradation
Author(s)
S. Evangelista, V. Yargeau & D. G. Cooper
Abstract
The presence of pharmaceutical compounds and their metabolites in aquatic
systems has become a concern in the past few years due, in part, to their ubiquity
in the environment. However, at present, the persistence and ecotoxicity of many
of these compounds remains unknown.
Clofibric acid is the active metabolite of clofibrate, a lipid regulator. It is
detected in most aquatic systems where pharmaceutical contaminants are
monitored and is reported to be persistent. (R)-mecoprop, a herbicide used on
broad-leaved crops, is a structural isomer of clofibric acid. However, unlike
clofibric acid, it can be degraded by at least some microorganisms including
Sphingomonas herbicidovorans and Alcaligenes denitrificans.
Biodegradation studies of both clofibric acid and its isomer mecoprop were
performed by exposing the compounds to axenic cultures of microorganisms in
shake flasks. While preliminary results revealed that clofibric acid was resistant
to microbial degradation with several types of microorganisms, it was shown that
Rhodococcus rhodochrous, a common soil microorganism, was capable of
converting clofibric acid to clofibrate, its parent compound. Despite the fact that
Sphingomonas herbicidovorans is capable of degrading (R)-mecoprop within a
couple of days, results indicated that it is incapable of degrading clofibric acid
under the same conditions. This suggests that the recalcitrance of clofibric acid is
due to change in the position of a methyl group with respect to (R)-mecoprop.
Keywords: clofibric acid, (R)-mecoprop, Sphingomonas herbicidovorans,
Rhodococcus rhodochrous, biodegradation.
Keywords
clofibric acid, (R)-mecoprop, Sphingomonas herbicidovorans,
Rhodococcus rhodochrous, biodegradation.
Related Book
Other papers in this volume
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