Modelling Of Blood Coagulation In
Cerebral Aneurysms
Author(s)
Y. Aida & K Shimano
Abstract
A fatal subarachnoid haemorrhage occurs when an intracranial aneurysm
ruptures and there are no guidelines for rupture risk assessment with perfect
reliability. Thrombus formation in stagnant flow condition has been said to play
an important role in rupture. However, there are, at present, no mathematical
models that allow us to simulate the whole process of thrombus formation in
aneurysms. In this study, the authors proposed a mathematical model of intraaneurysmal
coagulation so that the amount of fibrin generated in the aneurysm
can be calculated. It is known that coagulation is initiated by erythroelastase-IX
(EE-IX) in stagnant flow condition. This process is different from contact and
tissue factor pathways. In the present coagulation model, the reaction rate
constant of factor IX activation by EE-IX was determined. A group of reactions
in which anticoagulants are involved are treated as a whole so as to reduce
computational cost, and a quantity for the combined reaction rate constant is also
determined. It is demonstrated that the present coagulation model can reproduce
the rate of fibrin generation in a reference experiment at a reasonable
computational cost.
Keywords: intracranial aneurysm, rupture, stagnant blood flow, coagulation,
erythroelastase-IX.
Keywords
Keywords: intracranial aneurysm, rupture, stagnant blood flow, coagulation,
erythroelastase-IX.
Related Book
Other papers in this volume
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