Numerical Simulation Of Electromechanical
Activity Of The Gastric Smooth Muscle
Author(s)
O. A. Al-Qabandi & R. N. Miftahof
Abstract
A null-dimensional mathematical model of the myoelectrical activity of the
gastric smooth muscle (myofiber) is studied numerically. Based on real
morphological and electrophysiological data, the model assumes that: the
kinetics of L- and T-type Ca2+, Ca2+ -activated K+, voltage dependent K+ and Clchannels
determines the electrical activity of the myofiber; the enteric nervous
system is represented by the primary sensory and motor neurons; the pacemaker
input is provided by the interstitial cells of Cajal through receptor linked L-type
Ca2+channels located on the smooth muscle membrane. The dynamics of
propagation of the wave of depolarization along the unmyelinated nerve axons
satisfy the Hodgkin-Huxley model; the electrical activity of the neural soma
reflects the interaction of N-type Ca2+ channels, Ca2+ -activated K+ and voltage
dependent Na+, K+ and Cl- channels; and the smooth muscle is modeled as a nulldimensional
contractile system which dynamics is determined entirely by the
concentration of cytosolic calcium. The model reproduces: the mechanical
excitation of the free nerve endings of the mechanoreceptor of the receptive field
of the pathway; the electrical processes of the propagation of excitation along the
afferent and efferent neural circuits; the chemical mechanisms of nerve-pulse
transmission at the synaptic zones; the slow wave and bursting type electrical
activity; cytosolic calcium concentration; the dynamics of active force
generation. Results of numerical simulations of mechanical stimulation of the
gastric myofiber have revealed different mechanical responses. Thus, with
increased frequency and intensity of excitation there is a shift from phasic to
tonic bursting and the development of long-lasting contractions. Comparison of
theoretical and experimental results has revealed good qualitative and
quantitative agreement.
Keywords: numerical model, gastric myofiber, electromechanical activity.
Keywords
Keywords: numerical model, gastric myofiber, electromechanical activity.
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