Dermis Mechanical Behaviour:
Influence Of Cell Removal Treatment
Author(s)
A. L. Audenino, C. Bignardi, E. Businaro, C. Castagnoli,
M. Terzini & E. M. Zanetti
Abstract
The mechanical behaviour of skin is very important as regards dermatology,
surgery and impact trauma. Engineered skin substitutes can bring significant
medical benefit, in particular to patients with extensive burn wounds, even if
current skin substitutes do not restore normal skin anatomy and its natural
mechanical properties. This work considers the mechanical characterization of a
particular layer of skin: dermis. Dermis can be used as a filling material and as
support in different areas of reconstructive plastic surgery such as post
mastectomy reconstructive surgery and abdominal surgery. The aim was to
verify the influence of the decellularization treatment on its properties. The
specimens were subjected to uniaxial static tests performed with Bose
Electroforce® 3200 and experimental data were represented with engineering and
real time stress-strain curves. To begin, descriptive parameters were identified
for stress vs. strain curves, such as ultimate tensile strength and maximum
Young’s modulus, and they were subsequently compared through multivariate
analysis of variance to determine the influence of specimen cut orientation and
decellularization treatment duration. Dermis, that had been decellularized over 5
or 6 weeks, exhibited mechanical properties comparable with natural ones and
ultimate tensile strength and maximum Young’s modulus were shown to be
considerably higher in real time curves than in engineering ones.
Keywords: human dermis, static characterization, decellularization treatment.
Keywords
Keywords: human dermis, static characterization, decellularization treatment.
Related Book
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