Simulation Of Microcrack Growth And Repair
In Living Bone
Author(s)
P. Tisbo & D. Taylor
Abstract
The mechanics of how the bone can sustain, accumulate and ultimately repair
damage are an important part of biomechanical studies. This work wants to take
an analytical approach to the problem, trying to model a system that simulates
and predicts the behaviour of microcracks under various conditions of load and
other parameters. Materials and methods: this system is built with the
Simulink™ suite of the program Matlab™. It is composed of 3 sub models: the
first simulates microcrack growth under stress, the second simulates how the
damage done by the microcrack is translated into a biological signal and the third
mimics the cellular reactions that come into act to repair the damage. Results: the
system has been used to mimic what happens during experiments and the results
from experiments have been confronted to the outputs from the system. We have
compared the number of remaining cellular processes obtained in the simulation
with the number observed by using a SEM microscope on the tested specimen to
check how the damage signalling subsystem worked. The system has finally
been used to predict the cycle of damage accumulation and repair in military
trainee during the first weeks of training. Discussion: the results show that the
system predicts with good approximation the behaviour seen in the experiments
and statistics taken as a reference. The simulated microcracks grow until given
sizes and stop like in real bone, where they stop because of the osteons, and only
a number of them grow further, usually bringing the bone to failure. The number
of cracks that grow beyond this critical size is dependent by factors as stress
intensity and the distance between osteons, all modelled in the system. The
system is able to simulate the specific effects of diseases and aging on bone
fatigue behaviour.
Keywords: bone, simulation, microcracks, repair.
Keywords
Keywords: bone, simulation, microcracks, repair.
Related Book
Other papers in this volume
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