A Theoretical Study Of The Transient And
Steady-state Cardiorespiratory Response
To Exercise
Author(s)
E. Magosso & M. Ursino
Abstract
The cardiorespiratory adjustments during exercise have been analyzed through a
mathematical model. It includes central chemoreceptors, responding to carbon
dioxide in cerebral tissue, peripheral chemoreceptors, sensitive to arterial oxygen
and carbon dioxide pressure and to arterial potassium concentration, the
neurogenic mechanisms of exercise hyperpnea (including a fast and a slow
dynamics), and local blood flow regulation. The model is able to simulate with
good accuracy the cardiorespiratory adaptations clinically observed in response
to several patterns of exercise, both as to the steady-state and dynamic
conditions. In particular, the superimposition among the mechanisms included in
the model reproduces the temporal heterogeneity of the ventilation response to a
step work load during both the ON and OFF transitions. By using the model, the
mechanisms contributing to each temporal phase have been individuated, and the
functional importance of the different dynamics in the ventilatory response has
been quantitatively assessed. The model may be of value to suggest possible
scenarios able to interpret the complexity of ventilation control in exercise.
Keywords: mathematical models, ventilation control, exercise hyperpnea,
neurogenic mechanisms, peripheral and central chemoreceptors.
1 Introduction
During exercise, the greatly increased metabolic demand has to be matched by
an appropriate increase both of ventilation and blood flow, to provide a grater
amount of oxygen (O2) and to remove the excess of carbon dioxide (CO2)
production. In order this task is optimally performed, it is essential that several
and complex series of responses are controlled and coordinated.
Keywords
mathematical models, ventilation control, exercise hyperpnea,
neurogenic mechanisms, peripheral and central chemoreceptors.
Related Book
Other papers in this volume
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