Evaluation Of Insulin Sensitivity From
A Minimal Model Adapted To Oral Glucose Tests
Author(s)
F. Di Nardo, F. Casagrande, F. Carle, M. Boemi, P. Fumelli,
P. Morosini & R. Burattini
Abstract
Recently, we proposed a new methodology for clinical evaluation of insulin
sensitivity, SI, and the rate constant of glucose absorption, kabs, from oral glucose
tests. This methodology relies on a minimal model of glucose kinetics coupled
with a structural description of gastric emptying of glucose and its conversion
into the rate of systemic absorption from the gut. The aim of the present study
was to test the reproducibility of SI and kabs provided by our model using two
data sets from a 300 min frequently sampled oral glucose tolerance test: a full
22-sample data set (OGTT300/22) and a reduced 11-sample data subset
(OGTT300/11). Nine subjects, not affected by the metabolic syndrome,
participated in the study. Mean (95% confidence interval) values of 22
I S and
22
abs k obtained from the OGTT300/22 were 12.3 (8.8-15.8) ×10-4 min-1/(µU/ml) and
1.80 (1.31-2.29) ×10-2 min-1, respectively. Mean values of 11
I S and 11
abs k obtained
from the OGTT300/11 were 11.3 (7.6-15.0) ×10-4 min-1/(µU/ml) and 1.75 (1.19-
2.31) ×10-2 min-1, respectively. The concordance of the full and reduced paired
samples in providing SI and kabs estimates is supported by intraclass correlation
coefficients of 0.93 and 0.97, respectively. Parameter estimates and model based
simulations of the rate of glucose appearance into plasma, Ra(t), were
comparable with data in the literature. In conclusion, our model appears a
potentially useful tool to estimate insulin sensitivity and the rate constant of
systemic glucose absorption from reduced oral glucose tests.
Keywords: glucose kinetics, gastric emptying, gut model, OGTT.
Keywords
glucose kinetics, gastric emptying, gut model, OGTT.
Related Book
Other papers in this volume
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