Modelling Of The Effects Of Lotronex And
Zelnorm On Intestinal Propulsion
Author(s)
R. Miftahof
Abstract
A mathematical model of a segment of the gut to simulate propulsion of a solid
pellet (bolus) under physiological conditions and after administration of the
drugs – Lotronex (GSK) and Zelnorm (Novartis, AB) – is developed. The gut
containing a pellet is represented as a thin deformable soft biological shell with
the pellet modeled as a non-deformable solid. Mechanical properties of the gut
wall satisfy the general type of nonlinear orthotropy and deformations are finite.
Bolus propulsion is numerically simulated by generation and propagation of an
electromechanical wave of excitation along the wall. Pharmacological
manipulation is applied to model the effects of Lotronex and Zelnorm on the
dynamics of bolus progression. The results lead to new quantitative insights into
the complex spatio-temporal patterns of gastrointestinal transit. It is
demonstrated that the reciprocal relationship in contraction of the longitudinal
and circular smooth muscle syncytia is necessary to provide the "mixing" type of
movements during the preparatory phase of propulsion. Strong simultaneous
contractions of both smooth muscle layers are required to expel the "mixed"
pellet from the segment. The model is implemented as an interactive software
system, Gut Discovery ©, and accurately predicts the effects of drugs on gut
motility.
Keywords: pellet propulsion, mathematical model of the gut, effects of drugs.
1 Introduction
Despite considerable experimental progress in the past decade in the
understanding of the intricate biological mechanisms involved in the regulation
of gastrointestinal transit, our conceptual knowledge of the basic processes
responsible for intestinal movements is still lacking. This is mainly because of
Keywords
pellet propulsion, mathematical model of the gut, effects of drugs.
Related Book
Other papers in this volume
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