Cardiotherapeutical Results From The Coupled
BIOMED And GUYTON Models
Author(s)
J. Werner, C. Welp, D. Böhringer & M. Hexamer
Abstract
The GUYTON model is still the most comprehensive cardiovascular model with
a solid physiological background. However, it does not account for short term
pulsatile processes. We therefore developed a pulsatile model (BIOMED) of the
cardiovascular system and coupled it to the well documented modules of the
GUYTON model. The BIOMED model focuses on the systolic wall tension
progression, subject to the Frank-Starling- and Hill-mechanisms, and on the
simulation of the processes due to the cardiac valves.
After successful validation of the dynamics and the steady-state behaviour of
the decisive variables, pressure, volume and flow, by comparing them with
published experimental and clinical recordings, we used the coupled systems to
gain insight into the influences of impaired valve function and ventricular
relaxation disorders on cardiac output, the importance of atrial contraction to
ventricular filling, the significance of the choice of the adequate cardiac
pacemaker and the need for an implementation of an av-delay, dependent on
cardiovascular strain, in pacemakers.
This contribution focuses on the problem that pacemaker patients suffering
from diastolic relaxation disorders are particularly dependent on an adjusted avdelay
setting. The simulation results suggest the use of the derivative of
ventricular pressure, correlating with peak endocardial acceleration, to control
av-delay adaptation.
Keywords: pulsatile model, Guyton model, pacemaker, av-delay, relaxation
disorder, peak endocardial acceleration.
Keywords
pulsatile model, Guyton model, pacemaker, av-delay, relaxation
disorder, peak endocardial acceleration.
Related Book
Other papers in this volume
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