Modelling The Viscoelastic Properties Of
Coagulating Blood
Author(s)
P. R. Williams, R. L. Williams, K. Hawkins, C. Wright,
A. Evans & H. Simpkin
Abstract
The rheological behaviour of coagulating human blood has been measured using
a multiple frequency rheometrical technique known as Fourier Transform
Mechanical Spectroscopy (FTMS). The results indicate that coagulating blood,
prior to the point of incipient clot formation, can be modelled by a modified form
of the Gross-Marvin ‘ladder’ model, and the benefits of such modelling for blood
coagulation are discussed.
Keywords: rheology, blood coagulation, discrete relaxation spectra.
1 Introduction
A comprehensive understanding of the relationships between the microstructure
of blood clots and their viscoelastic properties has been a goal of clinical and
scientific research for more than 50 years. This goal remains largely unrealised,
due to the difficulty of describing the complex gel microstructure of blood clots
in conventional morphological terms, and a lack of appropriate rheological
techniques. The significance of this issue arises from findings that various
pathologies are associated with changes in the viscoelasticity of blood clots [1].
The present inability to relate these changes to underlying microstructural
changes prevents the development of a sufficient understanding of the processes
involved.
The most widely used rheological instrument used to study blood coagulation
is an oscillating-cylinder rheometer called a thromboelastograph (TEG). Since
1948, it has been used to monitor clot ‘rigidity’ in terms of cylinder displacement
Keywords
rheology, blood coagulation, discrete relaxation spectra.
Related Book
Other papers in this volume
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