Biomonitoring In Environmental
Medicine – Results Of LARS
Author(s)
U. Rolle-Kampczyk, U. Diez, M. Rehwagen, M. Richter,
M. Borte & O. Herbarth
Abstract
The Leipziger allergy risk study (LARS) investigated, during a period of five
years, the influence of a typical indoor contaminant burden on the development
of allergies and upper respiratory tract infections in children with an allergy-risk.
During the third year of life, biomonitoring with the focus on passive smoking
was carried out. Therefore, typical tobacco smoke related indoor volatile organic
compounds (VOC) as well as excretion of certain VOC metabolites in urine were
measured. The data analyses are based on parent-completed questionnaires,
exposure measurements and medical examination. Generally, residences with a
high burden of passive smoking showed higher benzene concentrations than nonsmoking
ones. Significant differences between the excretion of VOC metabolites
could be found between passive smoking and unburdened children. Obstructive
bronchitis was observed more frequently in the children being exposed to
increased concentrations of benzene as well as toluene, m,p-xylene and styrene.
In addition, occurrence of atopic symptoms like eczema was found to be
associated with the excretion of the VOC metabolite of toluene Sbenzyl-
mercapturic acid (SBMA). Therefore, evaluation of external exposure
should be supplemented with the evaluation of internal exposure.
Keywords: biomonitoring, passive smoking, allergy risk children, VOC,
metabolites.
Keywords
biomonitoring, passive smoking, allergy risk children, VOC,
metabolites.
Related Book
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