How To Predict The Potential Effect Of Chemicals
On Human Health: An Extended Question Of
Environmental Toxicology
Author(s)
A. Mueller, C. Graebsch, G. Wichmann, M. Bauer
& O. Herbarth
Abstract
Often the question is how you can decide whether a chemical affects human
health. The problem of human cells is that these cells loose some properties if
they have been isolated from the tissue. Considering this the single cell organism
Tetrahymena pyriformis was chosen. It is comparable in sensitiveness and
responsiveness to human tissue cells, is an organism and independent from tissue
and is a model for human respiratory epithelium-cell functionalities. The effects
of extracts bioaerosols (mould spores) and associated mycotoxins (gliotoxin and
penicilic acid) are of special interest. The following end points have been
investigated: viability (cell count), energy levels (adenosine-5’-triphosphate
content), and cell respiration (oxygen consumption). Effects on cell proliferation
and on physiological processes are suitable indicators for the different impact of
chemicals. T. pyriformis is a suitable organism to study effects of ubiquitous
chemicals.
Keywords: toxicology, model system, Tetrahymena pyriformis, mycotoxin
1 Introduction
A lot of chemicals have been detected in the environment. The problem is to
decide whether a chemical affects human health and human well being or not. To
Keywords
toxicology, model system, Tetrahymena pyriformis, mycotoxin
Related Book
Other papers in this volume
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