Cytogenetical And Histochemical Studies On
Curcumin In Male Rats
Author(s)
A. El-Makawy & H. A. Sharaf
Abstract
Curcumin is a major component of the curcuma species, commonly used as a
yellow coloring and flavoring agent in foods. Curcumin has been demonstrated
to have potent antioxidant, anti-inflammatory activity and has shown anticancer
properties in many rodent models. There is the perception that since compounds
are natural, they are devoid of toxicity and safe to use. Some of the active
compounds in supplements have inherent toxicity. In this study, five doses (0.5,
5, 10, 25 and 50 mg/kg/daily) of curcumin spice were orally administered to
male rats daily for four weeks. The effect of curcumin was studied genetically by
evaluation of chromosomal aberrations and micronucleus formation in bone
marrow cells of male rats. Histopathological and histochemical investigations
were studied in different tissues (liver, kidney) of males. The cytogenetical
results showed that curcumin caused a statistically significant dose-dependent
increase in the number of micronucleated polychromatic erythrocytes (MNPCEs)
and in the frequencies of total chromosomal aberrations over the control. Also,
results showed that there were significant differences between positive control
and all curcumin-tested doses, except the dose of 50 mg/kg showed no
significant difference. Histopathological results showed different degrees of
alterations, as manifested by vacuolar degeneration in hepatocytes, tubular
degeneration in renal tissues. We conclude that over use of curcumin spice may
cause genotoxical and histopathological effects.
Keywords: curcumin spice, ADI, bone marrow, chromosome aberrations,
micronucleus polychromatic erythrocytes (MNPCEs), liver, kidney.
Keywords
curcumin spice, ADI, bone marrow, chromosome aberrations,
micronucleus polychromatic erythrocytes (MNPCEs), liver, kidney.
Related Book
Other papers in this volume
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