Prolactin Levels Are Positively Correlated With
Polychlorinated Biphenyls (PCB) In Cord Serum
Author(s)
L. Takser, J. Lafond & D. Mergler
Abstract
Polychlorinated biphenyl compounds (PCB) are global environmental
contaminants that cause the disruption of endocrine and nervous systems in
animals and humans. However, little evidence exists showing their potential
interference with nervous system development following in utero exposure to
low PCB levels. The aim of this study is to examine cord serum prolactin (PRL)
levels in relation to cord blood concentrations of 14 PCB congeners in healthy
women recruited during pregnancy. Our results showed a significant increase of
cord serum PRL with an increasing level of PCB-153, the most prevalent PCB
congener. Thus, knowing that PRL release is under inhibitory dopamine
regulation, our results suggest that low level exposure to a mixture of persistent
environmental contaminants could interfere with dopaminergic transmission in
the fetal brain.
Keywords: PCB, prolactin, cord blood, environment.
1 Introduction
PCB are global pollutants characterized by their resistance to metabolic
degradation, their persistence contributes to their accumulation at the top of food
chain. Potential mechanisms underlying PCB-induced developmental
neurotoxicity are still unclear, but significant effects on dopamine metabolism
and thyroid function have been reported [1, 2]. In vitro studies suggest that signal
transduction pathways can be disrupted by PCB [3]. Recently, an interaction of
Keywords
PCB, prolactin, cord blood, environment.
Related Book
Other papers in this volume
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