Numerical Prediction Of The Focal Sites
Of Ozone-induced Tissue Injury
In The Respiratory Tract
Author(s)
B. Keshavarzi, J. Ultman & A. Borhan
Abstract
Numerical simulations of ozone transport and uptake in an anatomically-accurate
model of the respiratory tract of a Rhesus monkey were performed. The model
geometry was created using three-dimensional reconstruction of MRI images of
the respiratory tract, including the larynx and the first thirteen generations of
the tracheobronchial tree. An unstructured mesh was generated for the resulting
structure, and three-dimensional flow and concentration distributions were
obtained through numerical solution of the Navier-Stokes, continuity, and species
convection-diffusion equations. A quasi-steady diffusion-reaction model was used
to account for the interaction between O3 and endogenous substrates in the
respiratory tract lining fluid. Hotspots of O3 flux on the walls were identified for
steady inspiratory flow under quiet breathing conditions.
Keywords: ozone, uptake, respiratory tract, larynx, conducting airways.
Keywords
ozone, uptake, respiratory tract, larynx, conducting airways.
Related Book
Other papers in this volume
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